5 WARNINGS AND PRECAUTIONS

Sildenafil > sildenafil tables


Talk with your doctor if you’re pregnant or planning to become pregnant.

  • Sildenafil tablets work by inhibiting the enzyme PDE5, which increases blood flow.
  • They are not an aphrodisiac and require sexual stimulation to work effectively.
  • Sildenafil should not be used with nitrate medications due to risk of dangerous drops in blood pressure.

It appears unlikely that this drug will harm a pregnancy. However, this drug should only be used during pregnancy if clearly needed.

Contraindication Explanation Notes
Use with Nitrates Can cause severe hypotension Avoid concurrent use
Severe Cardiovascular Disease Increased risk of adverse events Consult a doctor before use
Hypotension (<90/60 mmHg) Risk of dangerously low blood pressure Avoid use in hypotensive patients

Viagra or generic sildenafil for ED should not be used in women. For women who are breastfeeding: When used for PAH, sildenafil may pass into breast milk and may cause side effects in a child who is breastfed.

  • Sildenafil tablets typically start working within 30 to 60 minutes after ingestion.
  • The effects of sildenafil tablets can last up to 4-6 hours.
  • Taking sildenafil with high-fat meals may delay its effectiveness.

Talk with your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication. For seniors: The kidneys, liver, or heart of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, a higher amount of a drug stays in your body for a longer time. This raises your risk for side effects.

  • Sildenafil tablets may interact with medications like alpha-blockers and certain antibiotics.
  • Overdose symptoms include severe hypotension, headache, and visual disturbances.
  • Always keep sildenafil tablets out of reach of children and pets.

For children: This drug isn’t recommended in children younger than 18 years. In one study, children with PAH who took this drug had an increased chance for death. All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on: how you react to the first dose Strengths: 25 mg, 50 mg, 100 mg Strengths: 25 mg, 50 mg, 100 mg Typical dosage: 50 mg, taken as needed about 1 hour before sexual activity. It can be taken 30 minutes to 4 hours before sexual activity. Maximum dosage: 100 mg once per day. This drug has not been confirmed to be safe or effective in children younger than 18 years.

6.2 Postmarketing Experience

If they’re more severe or don’t go away, talk with your doctor or pharmacist. Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following: Symptoms can include:blurry visionconfusiondizzinessfaintinglightheadednessnausea or vomitingsleepinessweakness Increased shortness of breath or trouble breathing Priapism (an erection that lasts more than 4 hours) Symptoms can include:sudden vision loss in one or both eyes sudden vision loss in one or both eyes Symptoms can include:sudden hearing losstinnitus (ringing in your ears)dizziness Heart problems, such as heart attack, stroke, or irregular heart rate. Symptoms can include:chest painshortness of breathdizzinesstrouble speakingconfusionnausea or vomitingfeeling lightheaded Priapism warning: This drug can cause priapism, which is an erection that won’t go away.

Azole Antifungals

If you have an erection that lasts more than 4 hours, call 911 or go to the nearest emergency room. If it’s not treated right away, this condition can cause permanent damage to your penis. Sudden vision loss warning: This drug can cause sudden vision loss in one or both eyes. This can be a sign of a serious eye problem. If this occurs, stop taking sildenafil and call your doctor right away.

Before taking sildenafil,

Sudden hearing loss warning: This drug can cause hearing loss, tinnitus (ringing in your ears), or dizziness. If you have sudden hearing loss with or without tinnitus or dizziness, stop taking sildenafil and call your doctor right away. Use in children warning: Children generally should not take sildenafil; however, there are instances where the drug is considered the best treatment option. Talk with your child’s doctor to better understand the benefits and risks associated with this treatment option. Sildenafil oral tablet can interact with other medications, vitamins, or herbs you may be taking. Senior dosage (ages 65 years and older) The kidneys, liver, or heart of older adults may not work as well as they used to. This raises your risk of side effects. Your doctor may start you on a lowered dosage of sildenafil.

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This can help prevent levels of this drug from building up in your body.

5.6 Combination with other PDE-5 Inhibitors

An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well. To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk with your doctor or pharmacist.

Revatio Tablets

Examples of drugs that can cause interactions with sildenafil are listed below. Do not take these drugs with sildenafil. Doing so can cause dangerous effects in the body. Nitrates, such as isosorbide mononitrate, isosorbide dinitrate, or nitroglycerin.Taking these drugs with sildenafil can cause your blood pressure to drop suddenly to an unsafe level. Taking these drugs with sildenafil can cause your blood pressure to drop suddenly to an unsafe level.

Serious Side Effects

Guanylate cyclase stimulators, such as riociguat.Taking these drugs with sildenafil can cause your blood pressure to drop suddenly to an unsafe level. Side effects from sildenafil: Taking sildenafil with certain medications raises your risk for side effects from sildenafil. This is because the amount of sildenafil in your body is increased. HIV drugs, such as ritonavir, indinavir, saquinavir, or atazanavir.Increased side effects can include low blood pressure, dizziness, or vision problems. They can also include erections that last longer than normal. Typical dosage: 5 or 20 mg, taken three times per day about 4 to 6 hours apart Maximum dosage: 20 mg, taken three times per day about 4 to 6 hours apart This drug shouldn’t be used in children younger than 18 years of age. Disclaimer: Our goal is to provide you with the most relevant and current information.

What side effects can this medication cause?

They can happen at any time, with or without symptoms. For people with sickle cell anemia: This drug may cause a common painful complication of sickle cell anemia called vaso-occlusive crisis. If you have sickle cell anemia, ask your doctor whether this drug is safe for you. For pregnant women: Research in animals has not shown a risk to the fetus when the mother takes the drug. However, there aren’t enough studies done in humans using the drug for PAH to show if the drug poses a risk to the fetus. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you.

  • Use caution when driving or operating machinery after taking sildenafil tablets.
  • Avoid excessive alcohol consumption when using sildenafil tablets, as it can increase side effects.
  • Consult your doctor before taking sildenafil if you have heart issues or low blood pressure.

Sildenafil oral tablet is used for short-term treatment of ED and long-term treatment of PAH. It comes with serious risks if you don’t take it as prescribed. If you stop taking the drug suddenly or don’t take it at all: For ED: Your ED symptoms won’t improve.

What other drugs will affect sildenafil?

Taking it again could be fatal (cause death). The use of drinks that contain alcohol raises your risk for low blood pressure from sildenafil. If you drink alcohol, talk with your doctor. You may need to have your blood pressure monitored while you take this drug. For people with heart problems: This drug can chew sildenafil lower your blood pressure.

Missed Dose

If you’ve had certain heart problems in the last 6 months, ask your doctor whether this drug is safe for you. These problems include a heart attack, stroke, or life threatening heart rhythm problem. Also talk with your doctor if you have a low or high resting blood pressure, or a history of heart failure or coronary artery disease. For people with pulmonary veno-occlusive disease (PVOD): Taking this drug may worsen your heart function. For people with eye problems: This drug may cause sudden loss of vision in one or both eyes.

Prior authorization

This may be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). If you’ve already had NAION or have crowded optic disc, you may have a higher risk for NAION and vision changes with this drug. For people with problems with the shape of their penis: If you have a problem with the shape of your penis, such as Peyronie’s disease, this drug raises your risk for having an erection that lasts more than 4 hours. For people with a history of stomach ulcers or bleeding: This drug raises your risk for stomach bleeding, ulcers, or small holes in the lining of your digestive system. These events can be fatal (cause death). For PAH: Your condition won’t improve and may get worse.

Brand names

Increased side effects can include low blood pressure, dizziness, or vision problems. Certain antibiotics, such as clarithromycin or erythromycin.Increased side effects can include low blood pressure, dizziness, or vision problems. Certain antifungals, such as ketoconazole or itraconazole.Increased side effects can include low blood pressure, dizziness, or vision problems. Side effects from other drugs: Taking sildenafil with certain medications raises your risk for side effects from these drugs. Alpha-blockers, such as terazosin, tamsulosin, doxazosin, alfuzosin, or silodosin.Increased side effects can include a drop in blood pressure, or fainting.

Drugs Affecting or Metabolized by Hepatic Microsomal Enzymes

Increased side effects can include a drop in blood pressure, or fainting. Blood pressure drugs, such as amlodipine.Increased side effects can include blood pressure that’s too low. Increased side effects can include blood pressure that’s too low. Other drugs for erectile dysfunction, such as avanafil, tadalafil, or vardenafil.Increased side effects can include low blood pressure or erections that last longer than normal Increased side effects can include low blood pressure or erections that last longer than normal Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions.

Raynaud's phenomenon

This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Sildenafil can cause a severe allergic reaction. If you develop these symptoms, call 911 or go to the nearest emergency room. Don’t take this drug again if you’ve ever had an allergic reaction to it. Also, you won’t be able to exercise. If you miss doses or don’t take the drug on schedule: For ED: Your ED symptoms won’t improve. For PAH: This medication may not work as well or may stop working completely.